解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Mutations in genes that encode tRNAs, aminoacyl-tRNA syntheases, tRNA modifying enzymes and other tRNA interacting partners are associated with neuropathies, cancer, type-II diabetes and hearing loss, but how these mutations cause disease is unclear. We have hypothesized that levels of tRNA decoding error (mistranslat...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.32199
更新日期:2014-01-01 00:00:00
abstract::The genus Xanthomonas comprises a large group of plant-pathogenic bacteria. The infection and bacterial multiplication in the plant tissue depends on the type III secretion system and other virulence determinants. Recent studies revealed that bacterial virulence is also controlled at the post-transcriptional level by ...
journal_title:RNA biology
pub_type: 杂志文章,评审
doi:10.4161/rna.28240
更新日期:2014-01-01 00:00:00
abstract::Heterogeneous nuclear ribonucleoprotein L (hnRNP L) is a multifunctional RNA-binding protein that is involved in many different processes, such as regulation of transcription, translation, and RNA stability. We have previously characterized hnRNP L as a global regulator of alternative splicing, binding to CA-repeat, a...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.27991
更新日期:2014-01-01 00:00:00
abstract::In plants, endogenes are less prone to RNA silencing than transgenes. While both can be efficiently targeted by small RNAs for post-transcriptional gene silencing (PTGS), generally only transgene PTGS is accompanied by transitivity, RNA-directed DNA methylation (RdDM) and systemic silencing. In order to investigate wh...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.29623
更新日期:2014-01-01 00:00:00
abstract::The RIG-I-like receptors (RLRs)--RIG-I, MDA5, and LGP2--detect intracellular pathogenic RNA and elicit an antiviral immune response during viral infection. The protein architecture of the RLR family consists of multiple functional domains, including N-terminal Caspase Activation and Recruitment Domains (CARDs) for sig...
journal_title:RNA biology
pub_type: 杂志文章,评审
doi:10.4161/rna.27717
更新日期:2014-01-01 00:00:00
abstract::Conserved RNA secondary structures were predicted in the nucleoprotein (NP) segment of the influenza A virus genome using comparative sequence and structure analysis. A number of structural elements exhibiting nucleotide covariations were identified over the whole segment length, including protein-coding regions. Calc...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.29730
更新日期:2014-01-01 00:00:00
abstract::The genome of most prokaryotes gives rise to surprisingly complex transcriptomes, comprising not only protein-coding mRNAs, often organized as operons, but also harbors dozens or even hundreds of highly structured small regulatory RNAs and unexpectedly large levels of anti-sense transcripts. Comprehensive surveys of p...
journal_title:RNA biology
pub_type: 杂志文章,评审
doi:10.4161/rna.28647
更新日期:2014-01-01 00:00:00
abstract::The development of rigorous molecular taxonomy pioneered by Carl Woese has freed evolution science to explore numerous cellular activities that lead to genome change in evolution. These activities include symbiogenesis, inter- and intracellular horizontal DNA transfer, incorporation of DNA from infectious agents, and ...
journal_title:RNA biology
pub_type: 杂志文章,评审
doi:10.4161/rna.27506
更新日期:2014-01-01 00:00:00
abstract::In a series of conceptual articles published around the millennium, Carl Woese emphasized that evolution of cells is the central problem of evolutionary biology, that the three-domain ribosomal tree of life is an essential framework for reconstructing cellular evolution, and that the evolutionary dynamics of functiona...
journal_title:RNA biology
pub_type: 杂志文章,评审
doi:10.4161/rna.27673
更新日期:2014-01-01 00:00:00
abstract::I am honored to have been asked to contribute to this memorial issue, although I cannot claim to have known Carl Woese well. Carl's insights and the discoveries that his research group made over the years certainly stimulated my own research program, and at several points early on, interactions with him were pivotal i...
journal_title:RNA biology
pub_type: 杂志文章,评审
doi:10.4161/rna.27799
更新日期:2014-01-01 00:00:00
abstract::"What does one do when the giants pass away?" remarked a very famous microbiologist to me, soon after the death of Carl Woese in late 2012. I teach microbiology and introductory cell and molecular biology at a small undergraduate institution; Woese's example and contributions have long been part of every class I teach...
journal_title:RNA biology
pub_type: 杂志文章,评审
doi:10.4161/rna.28002
更新日期:2014-01-01 00:00:00
abstract::MicroRNA (miRs) are short non-coding RNAs that fine-tune the regulation of gene expression to coordinate a wide range of biological processes. MicroRNAs are transcribed from miR genes and primary miR transcripts are processed to approximately 22 nucleotide single strand mature forms that function as repressors of tran...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.28141
更新日期:2014-01-01 00:00:00
abstract::In eukaryotes and viruses that infect them, the 5' end of mRNA molecules, and also many other functionally important RNAs, are modified to form a so-called cap structure that is important for interactions of these RNAs with many nuclear and cytoplasmic proteins. The RNA cap has multiple roles in gene expression, inclu...
journal_title:RNA biology
pub_type: 杂志文章,评审
doi:10.1080/15476286.2015.1004955
更新日期:2014-01-01 00:00:00
abstract::At low temperatures the Escherichia coli rpoS mRNA, encoding the stationary phase sigma factor RpoS, forms an intramolecular secondary structure (iss) that impedes translation initiation. Under these conditions the small RNA DsrA, which is stabilzed by Hfq, forms a duplex with rpoS mRNA sequences opposite of the ribos...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.27100
更新日期:2013-12-01 00:00:00
abstract::Processing bodies (P-bodies) are cytoplasmatic mRNP granules containing non-translating mRNAs and proteins from the mRNA decay and silencing machineries. The mechanism of P-body assembly has been typically addressed by depleting P-body components. Here we apply a complementary approach and establish an automated cell-...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.26851
更新日期:2013-11-01 00:00:00
abstract::The human genome encodes several thousand long non-protein coding transcripts>200 nucleotides in length, a subset of which were shown to play important roles in regulation of gene expression. We recently identified TINCR, a lncRNA required for induction of key differentiation genes in epidermal tissue, including genes...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.26249
更新日期:2013-10-01 00:00:00
abstract::High concentrations (> 100 µM) of the ribonucleoside analog 4-thiouridine (4sU) is widely used in methods for RNA analysis like photoactivatable-ribonucleoside-enhanced crosslinking and immunoprecipitation (PAR-CLIP) and nascent messenger (m)RNA labeling (4sU-tagging). Here, we show that 4sU-tagging at low concentrati...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.26214
更新日期:2013-10-01 00:00:00
abstract::In mammals, the genic disequilibrium between males (XY) and females (XX) is resolved through the inactivation of one of the X-chromosomes in females. X-chromosome inactivation (XCI) takes place in all mammalian species, but has mainly been studied in the mouse model where it was shown to be controlled by the interplay...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.25802
更新日期:2013-08-01 00:00:00
abstract::The acquisition of antibiotic resistance by human pathogens poses a significant threat to public health. The mechanisms that control the proliferation and expression of antibiotic resistance genes are not yet completely understood. The aminoglycosides are a historically important class of antibiotics that were introdu...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.25757
更新日期:2013-08-01 00:00:00
abstract::microRNAs (miRNAs) play significant regulatory roles in gene expression at the post-transcriptional level. This includes modulating processes such as development, immunity, cancer, and host-pathogen interactions. It was recently shown that the phylogenetically deeply conserved miRNA, miR-8, plays a role in maintaining...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.25481
更新日期:2013-08-01 00:00:00
abstract::Interactions between glioma cells and their local environment are critical determinants of brain tumor growth, infiltration and neovascularisation. Communication with host cells and stroma via microvesicles represents one pathway by which tumors can modify their surroundings to achieve a tumor-permissive environment. ...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.25281
更新日期:2013-08-01 00:00:00
abstract::Human Enterovirus 71 (EV71) is an emerging pathogen of infectious disease and a serious threat to public health. Currently, there are no antivirals or vaccines to slow down or prevent EV71 infections, thus underscoring the urgency to better understand mechanisms of host-enterovirus interactions. EV71 uses a type I int...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.25107
更新日期:2013-07-01 00:00:00
abstract::Prokaryotic immunity against foreign nucleic acids mediated by clustered, regularly interspaced, short palindromic repeats (CRISPR) depends on the expression of the CRISPR-associated (Cas) proteins and the formation of small CRISPR RNAs (crRNAs). The crRNA-loaded Cas ribonucleoprotein complexes convey the specific rec...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.23765
更新日期:2013-05-01 00:00:00
abstract::Prokaryotes immunize themselves against transmissible genetic elements by the integration (acquisition) in clustered regularly interspaced short palindromic repeats (CRISPR) loci of spacers homologous to invader nucleic acids, defined as protospacers. Following acquisition, mono-spacer CRISPR RNAs (termed crRNAs) guid...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.24023
更新日期:2013-05-01 00:00:00
abstract::MicroRNAs (miRNAs) are ubiquitous regulators of gene expression that contribute to almost any cellular process. Methods for managing of miRNA activity are attracting increasing attention in relation to diverse experimental and therapeutic applications. DNA-encoded miRNA inhibitors expressed from plasmid or virus-based...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.23543
更新日期:2013-03-01 00:00:00
abstract::Genuine La and La-related proteins group 7 (LARP7) bind to the non-coding RNAs transcribed by RNA polymerase III (RNAPIII), which end in UUU-3'OH. The La motif and RRM1 of these proteins (the La module) cooperate to bind the UUU-3'OH, protecting the RNA from degradation, while other domains may be important for RNA fo...
journal_title:RNA biology
pub_type: 杂志文章,评审
doi:10.4161/rna.23608
更新日期:2013-03-01 00:00:00
abstract::The Hedgehog (HH) signaling pathway has important roles in tumorigenesis and in embryonal patterning. The Glioma-associated oncogene 1 (GLI1) is a key molecule in HH signaling, acting as a transcriptional effector and, moreover, is considered to be a potential therapeutic target for several types of cancer. To extend ...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.23343
更新日期:2013-02-01 00:00:00
abstract::Pentatricopeptide repeat (PPR) proteins control diverse aspects of RNA metabolism across the eukaryotic domain. Recent computational and structural studies have provided new insights into how they recognize RNA, and show that the recognition is sequence-specific and modular. The modular code for RNA-binding by PPR pro...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.24769
更新日期:2013-01-01 00:00:00
abstract::In the last years, a number of nuclear genes restoring cytoplasmic male sterility (CMS) have been cloned in various crop species. The majority of these genes have been shown to encode pentatricopeptide repeat proteins (PPR) that act by specifically suppressing the expression of sterility-causing mitochondrial transcri...
journal_title:RNA biology
pub_type: 杂志文章,评审
doi:10.4161/rna.25568
更新日期:2013-01-01 00:00:00
abstract::MicroRNAs (miRNAs) are key regulators of gene expression and play critical roles in modulating metabolism, development and physiology in animals and plants. miRNA levels are transcriptionally and post-transcriptionally controlled for their proper function. Recent studies have shown that RNA-binding proteins play impor...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.22740
更新日期:2012-12-01 00:00:00
abstract::In eukaryotes, the 3' ends of RNA polymerase II-transcribed RNAs are generated in the majority of cases by site-specific endonucleolytic cleavage, followed by the addition of a poly(A) tail. Through alternative polyadenylation, a gene can give rise to multiple mRNA isoforms that differ in the length of their 3' UTRs a...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.22570
更新日期:2012-12-01 00:00:00
abstract::Changing the abundance of transcripts by regulated RNA degradation is a critical step in the control of various biological pathways. Recently, genome-wide inhibitor-free technologies for determining RNA stabilities in mammalian cells have been developed. In these methods, endogenous RNAs are pulse labeled by uridine a...
journal_title:RNA biology
pub_type: 杂志文章,评审
doi:10.4161/rna.22036
更新日期:2012-10-01 00:00:00
abstract::YchF is one of two universally conserved GTPases with unknown cellular function. As a first step toward elucidating YchF's cellular role, we performed a detailed biochemical characterization of the protein from Escherichia coli. Our data from fluorescence titrations not only confirmed the surprising finding that YchFE...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.22131
更新日期:2012-10-01 00:00:00
abstract::Contributions of dietary miRNAs to circulating small RNA profiles would have profound implications for interpretation of miRNA biomarker studies: presumptive disease-specific markers might instead indicate responses to disease-associated quantitative or qualitative dietary alteration. This examination weighs the evide...
journal_title:RNA biology
pub_type: 杂志文章,评审
doi:10.4161/rna.21619
更新日期:2012-09-01 00:00:00
abstract::The RNA component of the RNase P complex is found throughout most branches of the tree of life and is principally responsible for removing the 5' leader sequence from pre-tRNA transcripts during tRNA maturation. RNase P RNA has a number of universal core features, however variations in sequence and structure found in ...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.21502
更新日期:2012-09-01 00:00:00
abstract::Editing by ADAR enzymes is essential for mammalian life. Still, knowledge of the spatio-temporal editing patterns in mammals is limited. By use of 454 amplicon sequencing we examined the editing status of 12 regionally extracted mRNAs from porcine developing brain encompassing a total of 64 putative ADAR editing sites...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.21082
更新日期:2012-08-01 00:00:00
abstract::Bacterial small RNAs (sRNAs) are a class of structural RNAs that often regulate mRNA targets via post-transcriptional base pair interactions. We determined features that discriminate functional from non-functional interactions and assessed the influence of these features on genome-wide target predictions. For this pur...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.20294
更新日期:2012-07-01 00:00:00
abstract::MicroRNAs are small RNAs that post-transcriptionally regulate eukaryotic gene expression. In addition to their involvement in a wide range of physiological and pathological processes, including viral infections, microRNAs are increasingly implicated in the eukaryotic response to bacterial pathogens. Recent studies hav...
journal_title:RNA biology
pub_type: 杂志文章,评审
doi:10.4161/rna.20018
更新日期:2012-06-01 00:00:00
abstract::Viroids are the smallest autonomous infectious nucleic acids known today. They are non-coding, unencapsidated, circular RNAs with sizes ranging from 250 to 400 nucleotides and infect certain plants. These RNAs are transcribed by rolling-circle mechanisms in the plant host's nuclei (Pospiviroidae) or chloroplasts (Avsu...
journal_title:RNA biology
pub_type: 杂志文章,评审
doi:10.4161/rna.19810
更新日期:2012-06-01 00:00:00
abstract::Bacteria, like mammals, have to constantly defend themselves from viral attack. Like mammals, they use both innate and adaptive defense mechanisms. In this point of view we highlight the commonalities between defense systems of bacteria and mammals. Our focus is on the recently discovered bacterial adaptive immune sys...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.20177
更新日期:2012-05-01 00:00:00